PML was poorly understood until described in the findings of Grignani et al in their 1996 study of patients with acute promyelocytic leukemia (APL). PML mutation or loss, and the subsequent dysregulation of these processes, has been implicated in a variety of cancers. PML-NBs are known to have a number of regulatory cellular functions, including involvement in programmed cell death, genome stability, antiviral effects and controlling cell division. These nuclear bodies are present in mammalian nuclei, at about 1 to 30 per cell nucleus. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin of the cell nucleus. Promyelocytic leukemia protein ( PML) (also known as MYL, RNF71, PP8675 or TRIM19 ) is the protein product of the PML gene. positive regulation of nucleic acid-templated transcription.cellular response to leukemia inhibitory factor.regulation of signal transduction by p53 class mediator.positive regulation of transcription by RNA polymerase II.positive regulation of MHC class I biosynthetic process.negative regulation of mitotic cell cycle.entrainment of circadian clock by photoperiod.negative regulation of ubiquitin-dependent protein catabolic process. retinoic acid receptor signaling pathway.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress.regulation of double-strand break repair.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.maintenance of protein location in nucleus.negative regulation of transcription, DNA-templated.regulation of MHC class I biosynthetic process.circadian regulation of gene expression.positive regulation of apoptotic process involved in mammary gland involution.positive regulation of protein localization to chromosome, telomeric region.regulation of calcium ion transport into cytosol.intrinsic apoptotic signaling pathway by p53 class mediator.endoplasmic reticulum calcium ion homeostasis.positive regulation of apoptotic signaling pathway.positive regulation of fibroblast proliferation.branching involved in mammary gland duct morphogenesis.common-partner SMAD protein phosphorylation.regulation of transcription, DNA-templated.negative regulation of translation in response to oxidative stress.positive regulation of defense response to virus by host.negative regulation of cell population proliferation.proteasome-mediated ubiquitin-dependent protein catabolic process.transforming growth factor beta receptor signaling pathway.activation of cysteine-type endopeptidase activity involved in apoptotic process.positive regulation of extrinsic apoptotic signaling pathway.intrinsic apoptotic signaling pathway in response to DNA damage.positive regulation of telomere maintenance.negative regulation of telomerase activity.interferon-gamma-mediated signaling pathway.negative regulation of telomere maintenance via telomerase.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |